Nov 19, 2019   3:50 p.m. Alžbeta
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Course syllabus 426B2_4B - Biochemistry I (FCFT - SS 2018/2019)

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University: Slovak University of Technology in Bratislava
Faculty: Faculty of Chemical and Food Technology
Course unit title: Biochemistry I
Course unit code: 426B2_4B
Mode of completion and Number of ECTS credits: Exam (4 credits)
Name of lecturer: doc. Ing. Boris Lakatoš, PhD. (examiner, lecturer) - slovak, english
prof. RNDr. Ľudovít Varečka, DrSc. (person responsible for course) - slovak, english
Learning outcomes of the course unit:
The goal of this course is to teach students about the chemical composition of living matter, about enzymes, and about basics of energetic metabolism - degadation of saccharides and fatty acids and about biosyntheses of these compounds.
Prerequisites and co-requisites: none
Course contents:
Chemical composition of living organisms. Ions, trace elements, occurrence and function, role of water. Buffers. Energetics of living organisms. Equilibrium and noni-equilibrium processes. Chemical equilibria. Coupling of endergonic and exergonic reactions. High-energy bond.
DNA, structure, properties. DNA denaturation. Replication. Types, structures and functions of RNAs. Transcription. Genetic code. Enzymatic activity of RNA.
Amino acids, structure, properties, chemical reactions. Peptide bond. Proteins and polypeptides, their properties and structure. Methods of protein structure study. Proteosynthesis.
Monosaccharides. Stereochemistry. Biologically important monosaccharides, their derivatives, oligosaccharides and polysaccharides. Glycoside bond.
Fatty acids, triacylglycerols, waxes, sterols, complex lipids.
Enzymes. Enzymic reaction, kinetics, inhibition.
Cell metabolism and its regulation. Concept of operon by Jacob and Monod. Regulation by changes of enzymic activities.
Anaerobic and aerobic catabolism of glucose. Gluconeogenesis. Citric acid cycle. Anaplerotic reactions. Glyoxylate cycle. Pentose cycle. Oxidative phosphorylation. Respiratory chain. Coupling of substrate oxidation and ATP synthesis. Protonmotive force. Transport of reducing equivalents, substrates and products of phosphorylarion.
Utilization of fatty acids. Enzymologic, energetic, transport, and regulatory aspects.
Photosynthetic phosphorylation and carbon fixation. Dark-reactions of photosynthesis. Fixation of CO2 in C3 and C4 plants. Photorespiration. Calvin cycle
Recommended or required reading:
FERENČÍK, M. -- ŠKÁRKA, B. -- NOVÁK, M. -- TURECKÝ, L. Biochémia. Bratislava : SAP-Slovak Academic Press, 2000. 924 p. ISBN 80-88908-58-2.
VOET, D. -- VOET, J G. Biochemistry. New York : John Wiley & Sons, 1995. 1361 p. ISBN 0-471-58651-X.
STRYER, L. Biochemistry. New York : W.H.Freeman, 1988. 1089 p. ISBN 0-7167-1920-7.
VOET, D. -- VOET, J G. Biochemistry + CD-ROM. Danvers : John Wiley & Sons, 2004. 1591 p. ISBN 0-471-39223-5.

Planned learning activities and teaching methods: The course consists of 13 lectures, 2 h each.
Assesment methods and criteria: The course will be closed by both written and oral examinations.
Language of instruction: Slovak, English
Work placement(s): There is no compulsory work placement in the course unit.

Last modification made by Ing. Tomáš Molnár on 08/16/2018.

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