Jan 20, 2020   9:21 p.m. Dalibor
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Course syllabus N426M3_4I - Mechanisms of Action of Biologically Active Compounds (FCFT - WS 2020/2021)

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University: Slovak University of Technology in Bratislava
Faculty: Faculty of Chemical and Food Technology
Course unit title: Mechanisms of Action of Biologically Active Compounds
Course unit code: N426M3_4I
Mode of completion and Number of ECTS credits: Exam (4 credits)
Name of lecturer: prof. Ing. Albert Breier, DrSc. (person responsible for course) - slovak, english
Learning outcomes of the course unit:
Student is skilled in fundamental principles of cell mechanisms alteration by influence of biologically active chemical substance in relation to their target structure (substances integrating with DNA, substances altering protein expression on post-transcription level, substances with protective effects against damage induced by several pathological process developments, antimicrobial substances including antibiotics). Student also will obtain knowledge about possibilities of targeted treatment by substances influencing changed tissue function induced by pathological processes associated with development of several diseases.
Prerequisites and co-requisites: none
Course contents:
Effects of substances on biological systems and basics mechanisms of their effects; interaction of substances with DNA, substances induced DNA breaks, substances altering the processes of DNA repair and substances altering transcription; substances influencing cell proliferation, substances influencing protein expression on post-transcriptional levels including micro-RNA; examples of substances modulating enzyme activities and their applicability in therapy; examples of substances altering cell signaling and cell regulatory pathways; examples of substances influencing membrane transport and membrane potential and their applicability in therapy; substances buffering oxidative stress and substances operating against damage induced by ischemia and hypoxia of tissues including modulators of programmed cell death mechanisms; antimicrobial and antiviral substances and their applicability in therapy; examples of targeted therapy of different diseases (cardiovascular, cancer, metabolic, etc) with biologically active substances.
Recommended or required reading:
PATRICK, G. An Introduction to Medicinal Chemistry. Oxford: Oxford Univ.Press, 1995. 336 p. ISBN 0-19-855871-6.
THOMAS, G. Fundamentals of Medicinal Chemistry. Chichester : John Wiley & Sons, 2003. 285 p. ISBN 0-470-84306-3.

Planned learning activities and teaching methods: Lectures and seminars
Assesment methods and criteria: The course will be closed by written and oral examination.
Language of instruction: Slovak, English
Work placement(s): There is no compulsory work placement in the course unit.

Last modification made by Ing. Tomáš Molnár on 05/20/2019.

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