5. 4. 2020  19:57 Miroslava
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Sylabus predmetu N414S6_4I - Stereoselective Synthesis (FCFT - WS 2020/2021)


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University: Slovak University of Technology in Bratislava
Faculty: Faculty of Chemical and Food Technology
Course unit code: N414S6_4I
Course unit title: Stereoselective Synthesis
Mode of completion and Number of ECTS credits: Exam (5 credits)
Course contents:
1.Chirality (general concept) (allowance 6/4)
 
a.Phenomena of chirality, biological properties of optical antipods, selektívna synthesis of enantiomers and diastereomers, respectively. Kinetic resolution of eantiomers in asymmetric reaction.
b.Asymmetric synthesis: substrate selectivity, product selectivity, concept of stereodifferentiation and double control stereoselectivity.
c.Stereoselective synthetic strategies: chiron approach, template synthesis, asymmetric synthesis.

2.Principles of selected asymmetric reactions (allowance 12/12)
 
a.Additions to polar unsaturated bonds (1,2 , 1,3 asymmetric induction, models of TS).
b.Asymmetric epoxidation (Sharpless, Jacobssen Katsuki, Shi).
c.Asymmetric dihydroxylation, aminohydroxylation.
d.Asymmetric aldol and ene reactions (Zimmerman Traxler TS).
e.Organocatalysis.

3.Total syntheses (allowance 6/8)
 
a.Total syntheses of natural compounds (pheromones, inhibitors enzymes, cytotoxic compounds).


Last modification made by Ing. Tomáš Molnár on 05/20/2019.

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