Oct 18, 2019   12:54 p.m. Lukáš
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Course syllabus 414C0_4B - Drug chemistry (FCFT - WS 2019/2020)


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University: Slovak University of Technology in Bratislava
Faculty: Faculty of Chemical and Food Technology
Course unit code: 414C0_4B
Course unit title: Drug chemistry
Mode of delivery, planned learning activities and teaching methods:
lecture2 hours weekly (on-site method)

 
Credits allocated: 4
 
Recommended semester/trimester: -- item not defined --
Level of study: 1.
Prerequisites for registration: none
 
Assesment methods:
Elaboration of semestral work on: The Selected drug - properties, mechanism of action, methods of synthesis, analogous derivatives.
The exam consists of a written test and an oral test for 50 points. To successfully passing the exam, the student must achieve at least 28 points.
Students are grated as follows: A 46-50 points, B 41-45 points, C 37-40 points, D 32-36 points, E 28-31 points.
 
Learning outcomes of the course unit:
Subject is based on the knowledge of organic chemistry and biochemistry and gives basic information on the relationship between drug and its receptor at molecular level. It explains the strategic principles of drug development. In the interpretation are discussed selected categories of active substances in terms of their structural similarity, and mechanism of their action on molecular level.
 
Course contents:
Brief syllabus: mechanism of drug action, enzyme inhibitors, receptor theory, agonist, antagonist.
Developmental stages of drug synthesis, lead structure, synthesis of analogs, synthetic strategies.
Total anesthetics, analgesics, morphine analogs.
Antipyretics, non-steroidal anti-inflammatory drugs.
Peripheral nervous system drugs, cholinergic system, local anesthetics, muscle relaxants.
Adrenergics, adrenolytic agents, ergot alkaloids.
Antihistamines, H1 and H2 developments of antihistamines.
Antibacterials - sulfonamides, antibiotics - penicillins and cephalosporins.
Disinfectants, antiseptics and antifungals.
Antivirals.
Antineoplastic agents.
Vitamins A, E, respectively. C and Group B.
 
Recommended or required reading:
Basic:
BERKEŠ, D. -- VINŠOVÁ, J. -- KUTSCHY, P. -- TOROK, M. Základy farmaceutickej chémie. Košice: Univ. P. J. Šafárika, 2003. 150 p.
LÜLLMANN, H. -- MOHR, K. -- LUTZ, H. Barevný atlas farmakologie: překlad 5., přepracovaného a rozšíreného vydání. Praha : Grada Publishing, 2007. 384 p. ISBN 978-80-247-1672-5.
PATRICK, G L. An Introduction to Mediinal Chemistry. New York: Oxford University Press Inc., 2009. 752 p. ISBN 978-0-19-923447-9.

 
Language of instruction: slovak or english
 
Notes:
The course is recommended for students in the third year of study in the program Nutrition and cosmetics
 
Courses evaluation:
Assessed students in total: 354

ABCDEFX
9,0 %17,5 %24,6 %20,3 %27,7 %0,9 %
Name of lecturer(s): Ing. Matej Babjak, PhD. (examiner, lecturer, tutor) - slovak, english
doc. Ing. Dušan Berkeš, CSc. (person responsible for course) - slovak, english
 
Last modification: 29. 1. 2019
Supervisor: doc. Ing. Dušan Berkeš, CSc. and programme supervisor


Last modification made by Ing. Tomáš Molnár on 01/29/2019.

Type of output: