Oct 19, 2020   5:38 p.m. Kristián
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Course syllabus N414S4_4I - Synthesis of Natural Compounds and Drugs (FCFT - WS 2019/2020)

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Slovak University of Technology in Bratislava
Course unit code:
Course unit title: Synthesis of Natural Compounds and Drugs
Mode of delivery, planned learning activities and teaching methods:
2 hours weekly (on-site method)
1 hour weekly (on-site method)

Credits allocated: 4
Recommended semester/trimester:
Technical Chemistry - master (semi-compulsory), 3. semester
Level of study:
Prerequisites for registration:
Assesment methods:
Elaboration of semestral work on: The Selected drug - properties, mechanism of action, methods of synthesis, analogous derivatives.
The exam consists of a written test and an oral test for 50 points. To successfully passing the exam, the student must achieve at least 28 points.
Students are grated as follows: A 46-50 points, B 41-45 points, C 37-40 points, D 32-36 points, E 28-31 points.
Learning outcomes of the course unit:
Subject builds on the knowledge of organic chemistry and medical chemistry and gives basic information on the relationship between drug - receptor at the molecular level. It explains the strategic principles that apply to drug development. In the interpretation are discussed selected categories of active substances in terms of their structural similarity, respectively. mechanism of action at the molecular level. Practice in the synthesis of selected commercial drugs.
Course contents:
The mechanism of action of drugs, enzyme inhibitors, receptor theory, agonist, antagonist drug development phase synthesis, supporting structure, synthesis of analogs, synthetic strategies - examples of the development and synthesis of ACE inhibitors. Development and synthesis of drugs for Parkinson's and Alzheimer's diseases
GABA receptors - sedatives, hypnotics, synthesis of pharmacologically active benzodiazepines, barbiturates.
Psychotics - mechanism of action and synthesis of selected psychotics and psychoanaleptics
Antimalarials - mechanism of action, natural and synthetic endoperoxides, synthesis of selected derivatives
Ulcer Treatment - H2 antihistamines and proton pump inhibitors, Synthesis of esomeprazole, racemic switch
Healing the digestive system mechaniázmus effect a synthesis of selected antacids, hepatoprotektík, antidiabetics and diuretics.
The active substances of the circulatory system - mechanism of action and symtéza selected antihyperlipidemím, antithrombotic drugs and vasodilators.
Antivirals - mechanism of action and synthesis of selected active pharmaceutical ingredients known as antimetabolites. Known drugs for AIDS and flu nucleoside and non-nucleoside type.
The treatment of cancer - a mechanism of synthesis of selected antineoplastic agents.
Recommended or required reading:
HAMPL, F. -- PALEČEK, J. Farmakochemie. Praha : Vydavatelství VŠCHT, 2002. 413 p. ISBN 80-7080-495-5.
PATRICK, G L. An Introduction to Mediinal Chemistry. New York: Oxford University Press Inc., 2009. 752 p. ISBN 978-0-19-923447-9.
PATRICK, E A. Osnovy teorii raspoznavanija obrazov = Fundamentals of pattern recognition. Moskva : Sovetskoje radio, 1980. 407 p.

Language of instruction:
slovak or english
The course is recommended for students in the second year of enginiering study in the program Technical chemistry
Courses evaluation:
Assessed students in total: 67

65,7 %
25,4 %8,9 %
0 %
0 %
0 %
Name of lecturer(s):
doc. Ing. Dušan Berkeš, CSc. (examiner, instructor, lecturer, person responsible for course, tutor) - slovak, english
Ing. Pavol Jakubec, PhD. (examiner, instructor, lecturer) - english
Last modification:
29. 1. 2019
doc. Ing. Dušan Berkeš, CSc. and programme supervisor

Last modification made by Ing. Tomáš Molnár on 01/29/2019.

Type of output: