Oct 21, 2019   1:40 a.m. Uršuľa
Academic information system

Course syllabus 431X0_4B - Xenobiochemistry (FCFT - WS 2019/2020)


     Information sheet          ECTS          Syllabus          


     Slovak          English          


University: Slovak University of Technology in Bratislava
Faculty: Faculty of Chemical and Food Technology
Course unit code: 431X0_4B
Course unit title: Xenobiochemistry
Mode of delivery, planned learning activities and teaching methods:
lecture2 hours weekly (on-site method)

 
Credits allocated: 2
 
Recommended semester/trimester: -- item not defined --
Level of study: 1.
Prerequisites for registration: none
 
Assesment methods:
running and final test
 
Learning outcomes of the course unit:
By studying the curriculum, students will acquire knowledge on the penetration of the xenobiotic compounds into environment, as well as on their transport in the natural milieu, and biochemical transformations thereof. The subject is based on the chemical and biochemical data, while in contrast to biochemistry, it is aimed at the transformations of the non-biological substances with the stress being put on the compounds exerting harmful activity towards health and the environment (e.g. chlorinated and polycyclic aromatics), toxicity, bioaccumulation, and persistence. Understanding of the relationships between the structure of the organic compounds and their biodegradability, and possibility of production of the toxic products during the metabolic transformation, mechanisms of action of xenobiotics-endocrinne disruptors damaging DNA in organisms is being emphasized.
 
Course contents:
Anthropogenic compounds, principle of their persistence and biodegradation. Persistence, toxicity and bioaccumulation of the organic pollutants. Physical and chemical properties as the factor determining behavior of the compounds in biological systems. Distribution and fate of xenobiotics in the organism. Interactions of xenobiotic molecules with a cell. Quantitative structure-activity relationships and quantitative structure-biodegradability relationships in xenobiotics. Biological degradability of organic compounds and potential toxicity of some by-products or end-products of their transformation. Toxicological aspects of the xenobiotics metabolism. Role of microbial enzymes in degradation of xenobiotics in the environment. Metabolism and cometabolism. Aerobic and anaerobic degradation of xenobiotics. Use of genetically modified microorganisms and transgenic plants at biodegradation of xenobiotics -- contaminants of the environment. Metabolic degradation pathways of aliphatic, halogenated aromatic, condensed, and polycondensed aromatic compounds.
 
Recommended or required reading:
Basic:
HELIA, O. -- PAULIKOVÁ, I. Xenobiochémia. Bratislava : Farmaceutická fakulta UK v Bratislave, 2004. 67 p. ISBN 80-223-1796-9.
FERENČÍK, M. -- ŠKÁRKA, B. -- NOVÁK, M. -- TURECKÝ, L. Biochémia. Bratislava : SAP-Slovak Academic Press, 2000. 924 p. ISBN 80-88908-58-2.

 
Language of instruction: slovak or english
 
Notes:
 
Courses evaluation:
Assessed students in total: 425

ABCDEFX
48,0 %29,9 %16,2 %4,9 %1,0 %0 %
Name of lecturer(s): doc. Ing. Katarína Dercová, PhD. (person responsible for course) - slovak, english
 
Last modification: 29. 1. 2019
Supervisor: doc. Ing. Katarína Dercová, PhD. and programme supervisor


Last modification made by Ing. Tomáš Molnár on 01/29/2019.

Type of output: