Sep 18, 2019   9:01 a.m. Eugénia
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Course syllabus N431X0_4B - Xenobiochemistry (FCFT - SS 2019/2020)

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University: Slovak University of Technology in Bratislava
Faculty: Faculty of Chemical and Food Technology
Course unit code: N431X0_4B
Course unit title: Xenobiochemistry
Mode of delivery, planned learning activities and teaching methods:
lecture2 hours weekly (on-site method)

Credits allocated: 3
Recommended semester/trimester: Biotechnology - bachelor (compulsory), 6. semester
Level of study: 1.
Prerequisites for registration: none
Assesment methods:
final test
The evaluation of both tests is equivalent.
Evaluation A-FX (minimal 56% from 100%).
10 questions, for each 10 points = summary 100 points
evaluation: percentage of successfulness
A: 92-100
B: 83-91
C: 74-82
D: 65-73
E: 56-64
FX: 0-55
Learning outcomes of the course unit:
By studying the curriculum, students know knowledge on the penetration of the xenobiotic compounds into environment, as well as on their fate and transport in the natural milieu, and biochemical transformations in organisms thereof. The subject is aimed at the microbial transformation of persistent non-biological substances, pollutants of the environment exerting harmful activity towards health of human population and the environment (e.g. chlorinated polycyclic aromatics). Understanding of the relationships between the structure of the organic compounds and their biodegradability, properties of xenobiotics (toxicity, persistence, hydrophobicity, and bioaccumulation), catabolic pathways of degradation, and possibility of production of the toxic products during the metabolic transformation are being emphasized.
Course contents:
Anthropogenic compounds, principle of their persistence and biodegradation. Persistence, toxicity and bioaccumulation of the organic pollutants. Physical and chemical properties as the factor determining behavior of the compounds in biological systems. Distribution and fate of xenobiotics in the organism. Interactions of xenobiotic molecules with a cell. Quantitative structure-activity relationships and quantitative structure-biodegradability relationships in xenobiotics. Biological degradability of organic compounds and potential toxicity of some by-products or end-products of their transformation. Toxicological aspects of the xenobiotics metabolism. Role of microbial enzymes in degradation of xenobiotics in the environment. Metabolism and cometabolism. Aerobic and anaerobic degradation of xenobiotics. Pharmaceuticals as new environmental pollutants. Use of genetically modified microorganisms and transgenic plants at biodegradation of xenobiotics -- contaminants of the environment. Metabolic degradation pathways of aliphatic, halogenated aromatic, condensed, and polycondensed aromatic compounds.
Recommended or required reading:
FERENČÍK, M. -- ŠKÁRKA, B. -- NOVÁK, M. -- TURECKÝ, L. Biochémia. Bratislava : SAP-Slovak Academic Press, 2000. 924 p. ISBN 80-88908-58-2.
HELIA, O. -- PAULIKOVÁ, I. Xenobiochémia. Bratislava : Farmaceutická fakulta UK v Bratislave, 2004. 67 p. ISBN 80-223-1796-9.

Language of instruction: slovak or english
Courses evaluation:
Assessed students in total: 86

43,0 %25,6 %19,8 %11,6 %0 %0 %
Name of lecturer(s): doc. Ing. Katarína Dercová, PhD. (person responsible for course) - slovak, english
Last modification: 21. 2. 2019
Supervisor: doc. Ing. Katarína Dercová, PhD. and programme supervisor

Last modification made by Ing. Tomáš Molnár on 02/21/2019.

Type of output: