Oct 19, 2020   6:22 p.m. Kristián
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Course syllabus N426Z7_4B - Principles of Clinical Biochemistry (FCFT - SS 2019/2020)

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Slovak University of Technology in Bratislava
Course unit code:
Course unit title:
Principles of Clinical Biochemistry
Mode of delivery, planned learning activities and teaching methods:
2 hours weekly (on-site method)

Credits allocated:
Recommended semester/trimester:
Biotechnology - bachelor (semi-compulsory), 6. semester
Level of study: 1.
Prerequisites for registration:
Assesment methods:
Successful oral examination. Oral examination consists of written test and oral communication. Maximum number of points from test is 80 and maximum 20 points student obtains from oral communication. Students have to reach at least 44 point from written test to pass to oral communication.
Learning outcomes of the course unit:
Student is familiar with the role of clinical biochemistry in medicine, he understands the methods of selection of biochemical tests and he is familiar with analytical and diagnostic properties of tests. Student knows the techniques of test`s quality and laboratory practice management and assessment. Student understands the importance of biochemical tests in diagnostics of diseases. Student comprehends the relationship between the genes and genesis and progress of diseases.
Course contents:
1. Role of clinical biochemistry in medicine
a. Reference values in clinical biochemistry. Selection of biochemical tests, sensibility and specificity.
b. Monitoring and control of analytical process quality. Analytical methods in clinical biochemistry.

2. Biomolecules in diagnostics of diseases
a. Disorders in carbohydrates metabolism - laboratory diagnostics. Diabetes mellitus and its forms.
b. Disorders of lipid metabolism and lipoproteins - relation to atherosclerosis. Lipid parameters values and their assessment as risk factor.
c. Blood plasma proteins, their use in diagnostics of diseases. Proteins, enzymes, hormones as a tumour narkers.
d. Test of enzyme activities in biological fluids and possibilities of use in diagnostics of several organs diseases.

3. Diagnostics of organ diseases
a. Diagnostics of liver diseases, heart diseases, gastrointestinal tract.
b. Low-molecular nitrogen compounds in blood and urine, assessment of kidney function. Metabolism of porphyrins.

4. Inherited metabolic diseases and disorders in acid-base balance
a. Disorders in aminoacids and carboxylic acids metabolism. Most frequented monogenic diseases. Other monogenic diseases of carbohydrate metabolism
b. Acid-base balance tests: respiratory and metabolic acidosis and alkalosis. Tests of management with water and electrolytes.

5. Hormones and trace elements
a. Metabolism of calcium and phosphates. Trace elements and their significance in medicine.
b. Endocrinopathies - tests of function
Recommended or required reading:
RACEK, J. Klinická biochemie. Praha: Galén, 1999. 317 p. ISBN 80-7262-023-1.
MURRAY, R K. Harper's Biochemistry. New York : McGraw-Hill, 2000. 927 p. ISBN 0-8385-3684-0.
DEVLIN, T M. Textbook of Biochemistry with Clinical Correlations. New York : Wiley-Liss, Inc, 1997. 1186 p. ISBN 0-471-15451-2.
SÁDECKÁ, J. -- NETRIOVÁ, J. Analytické metódy v klinickej chémii. Bratislava : STU v Bratislave, 2008. 272 p. ISBN 978-80-227-2821-8.

Language of instruction:
slovak or english
Courses evaluation:
Assessed students in total: 68

11,8 %32,4 %17,6 %
23,5 %
14,7 %
0 %
Name of lecturer(s):
doc. Ing. Boris Lakatoš, PhD. (person responsible for course) - slovak, english
Last modification:
29. 1. 2019
doc. Ing. Boris Lakatoš, PhD. and programme supervisor

Last modification made by Ing. Tomáš Molnár on 01/29/2019.

Type of output: