Oct 23, 2020   11:41 a.m. Alojza
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Course syllabus N414C1_4B - Chémia liečiv (FCFT - SS 2019/2020)

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Slovak University of Technology in Bratislava
Faculty of Chemical and Food Technology
Course unit code: N414C1_4B
Course unit title:
Chémia liečiv
Mode of delivery, planned learning activities and teaching methods:
2 hours weekly (on-site method)

Credits allocated: 3
Recommended semester/trimester:
-- item not defined --
Level of study:
Prerequisites for registration:
Assesment methods:
Elaboration of semestral work on: The Selected drug – properties, mechanism of action, methods of synthesis, analogous derivatives.
The exam consists of a written test and an oral test for 50 points. To successfully passing the exam, the student must achieve at least 28 points.
Students are grated as follows: A 46-50 points, B 41-45 points, C 37-40 points, D 32-36 points, E 28-31 points.
Learning outcomes of the course unit:
Subject is based on the knowledge of organic chemistry and biochemistry and gives basic information on the relationship between drug and its receptor at molecular level. It explains the strategic principles of drug development. In the interpretation are discussed selected categories of active substances in terms of their structural similarity, and mechanism of their action on molecular level.
Course contents:
mechanism of drug action, enzyme inhibitors, receptor theory, agonist, antagonist.
Developmental stages of drug synthesis, lead structure, synthesis of analogs, synthetic strategies.
Total anesthetics, analgesics, morphine analogs.
Antipyretics, non-steroidal anti-inflammatory drugs.
Peripheral nervous system drugs, cholinergic system, local anesthetics, muscle relaxants.
Adrenergics, adrenolytic agents, ergot alkaloids.
Antihistamines, H1 and H2 developments of antihistamines.
Antibacterials – sulfonamides, antibiotics – penicillins and cephalosporins.
Disinfectants, antiseptics and antifungals.
Antineoplastic agents.
Vitamins A, E, respectively. C and Group B.
Recommended or required reading:
BERKEŠ, D. -- VINŠOVÁ, J. -- KUTSCHY, P. -- TOROK, M. Základy farmaceutickej chémie. Košice: Univ. P.J.Šafárika, 2003. 150 p.
PATRICK, G L. An Introduction to Mediinal Chemistry. New York: Oxford University Press Inc., 2009. 752 p. ISBN 978-0-19-923447-9.

HAMPL, F. -- PALEČEK, J. Farmakochemie. Praha : Vydavatelství VŠCHT, 2002. 413 p. ISBN 80-7080-495-5.
ZIEGLER, A. -- MOHR, K. -- LULLMANN, H. Barevný atlas farmakológie. Praha: GrRADA, 2001. 392 p. ISBN 80-7169-973-X.

Language of instruction:
slovak or english
Courses evaluation:
Assessed students in total: 0

Name of lecturer(s):
doc. Ing. Dušan Berkeš, CSc. (person responsible for course) - slovak, english
Last modification:
27. 4. 2020
Supervisor: doc. Ing. Dušan Berkeš, CSc. and programme supervisor

Last modification made by Samuel Hraško on 04/27/2020.

Type of output: