Oct 1, 2020   1:00 a.m. Arnold
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Course syllabus N426V0_4B - Vývoj liečiv (FCFT - SS 2019/2020)

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University: Slovak University of Technology in Bratislava
Faculty: Faculty of Chemical and Food Technology
Course unit code: N426V0_4B
Course unit title:
Vývoj liečiv
Mode of delivery, planned learning activities and teaching methods:
2 hours weekly (on-site method)

Credits allocated:
Recommended semester/trimester:
-- item not defined --
Level of study:
Prerequisites for registration: none
Assesment methods:
2 x written/oral examination of acquired knowledge.
Learning outcomes of the course unit:
The student will gain basic knowledge about drug development, their categorization and target structures. The acquired knowledge will include knowledge of:
1.Definition of target drug structures and examples of basic drug interactions and its purpose.
2.Physico-chemical properties of drugs (acid-base properties, hydrophilicity versus lipophilicity), molecular descriptors defining these properties of drugs and methods for numerical and experimental determination of these descriptors.
3. Procedures for determining the quantitative relationships between the structure of the active substance and its biological activity.
4. The use of modern methods of theoretical chemistry and structural biology and the possibility of modeling and optimizing effective drug structures using the methods of molecular docking of the active substance at the binding site of the receptor structure.
5. Methods of testing the biological effects of drugs and accurate identification of their side effects and risks during application.
6.Possibilities of drug application and various dosage forms.
Course contents:
1. Introduction to the issue; historical overview of procedures and the impact of the issue development on the health of the individual; definition of the current state and possible direction of further development; categorization of drugs.
2. Mechanisms of action and target structures of drugs, examples of drug function.
3. Physicochemical properties of drugs acido-base ans lipophilic-hydrophilic properties of drugs and their relation to the nature of the putative receptor.
4. Natural synthetic and semisynthetic drugs and some examples. Strategy and intention of drug development - past, present and vision for the future.
5. Distribution of drugs in the body, their passage through various barriers, phase interfaces, passive and active transport of substances across biological membranes.
6. Determination of kinetics and equilibria of drug interactions with target structures (receptors) and radioligand studies.
7. Methodology of rational drug design - investigation of quantitative relationships between drug structure and their efficacy.
8. Methodology of drug structure optimization using modeling by molecular drug docking in the target structure.
9. Modern analytical procedures in the detection of drug-receptor interactions and their impact on molecular modeling.
10. Possibilities of targeted distribution of drugs to a specific tissue - drug addressing.
11. Methods of administration of drugs and corresponding dosage forms.
12. Drug testing and approval procedures, FDA (Food and Drug Agency) and EMEA (European Medicines Evaluation Agency) methodology.
13. Biotransformation of drugs and its influence on their effectiveness.
Recommended or required reading:
Language of instruction:
slovak and english
Courses evaluation:
Assessed students in total: 0

Name of lecturer(s):
Ing. Matej Babjak, PhD. (examiner, lecturer) - slovak, english
prof. Ing. Albert Breier, DrSc. (examiner, lecturer, person responsible for course) - slovak, english
Last modification:
14. 5. 2020
prof. Ing. Albert Breier, DrSc. and programme supervisor

Last modification made by Samuel Hraško on 05/14/2020.

Type of output: