Oct 20, 2020   1:56 a.m. Vendelín
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Course syllabus 443B1_4D - Bioenergetics of Cells and Organisms (FCFT - 2019/2020 - post-graduate studies)

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Slovak University of Technology in Bratislava
Course unit code: 443B1_4D
Course unit title:
Bioenergetics of Cells and Organisms
Mode of delivery, planned learning activities and teaching methods:
5 hours weekly (on-site method)

Credits allocated:
Recommended semester/trimester: Biochemistry - doctoral (semi-compulsory), 1. year
Level of study:
Prerequisites for registration: none
Assesment methods:
There is no monitoring of students knowledge during the course.
Learning outcomes of the course unit:
The goal of this course is to summarize contemporary knowledge about the energy transformation in cells leading to the synthesis of ATP and and other high-energy compounds in Prokarya, Eukarya and Archaea. The process of teaching will be concentrated on the role of proton-motive force and on the substrate phosphorylation under aerobic and anaerobic conditions.
Course contents:
Introduction to bioenergetics. Coupling of an exergonic to an endergonic reaction. Transfer of free energy from an exergonic to an endergonic reaction via a high-energy intermediate compound. Redox cycle of the biosphere.
The diversity of membrane proteins. Mechanisms of molecular biological membrane transport. Classes of bioenergetic processes: fermentation, photosynthesis and respiration. Substrate-level phosphorylation. High-energy phosphate compounds. Role of ATP/ADP cycle in transfer of high-energy phosphate. Energy charge.
The citric acid cycle. Organization and function of coupling membrane. Mitochondrion. Structure of mitochondrial membranes. Mitochondrial enzymes. Chloroplasts
Respiratory chain, production of ATP. Electron transport and oxidative phosphorylation. Components of respiratory chain. The mechanism of chemiosmotic coupling of electron transport and oxidative phosphorylation.
Fractionation and reconstitution of mitochondrial respiratory chain complexes.
Inhibitors of respiratory chain complexes. Uncouplers of oxidative phosphorylation. Inhibitors of oxidative phosphorylation. Ionofores. Endogenous uncouplers.
ATP formation under anaerobic conditions and in anaerobic microorganisms.
Recommended or required reading:
NICHOLLS, D. Bioenrgetics. London: Elsevier, 2002.

Language of instruction:
slovak and english
Courses evaluation:
Assessed students in total: 50

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Name of lecturer(s):
prof. Ing. Albert Breier, DrSc. (examiner, instructor, lecturer) - slovak, english
doc. Ing. Martin Šimkovič, PhD. (examiner, instructor, lecturer, person responsible for course, tutor) - slovak, english
Last modification: 26. 4. 2019
doc. Ing. Martin Šimkovič, PhD. and programme supervisor

Last modification made by Ing. Tomáš Molnár on 04/26/2019.

Type of output: