Oct 19, 2020   6:28 p.m. Kristián
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Course syllabus N400G0_4D - Genomics, Proteomics and Their Applications (FCFT - 2019/2020 - post-graduate studies)

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University: Slovak University of Technology in Bratislava
Course unit code: N400G0_4D
Course unit title:
Genomics, Proteomics and Their Applications
Mode of delivery, planned learning activities and teaching methods:
10 hours weekly (on-site method)

Credits allocated:
Recommended semester/trimester:
Biochemistry - doctoral (semi-compulsory), 2. year
Biochemistry - doctoral (semi-compulsory), 2. year
Level of study: 3.
Prerequisites for registration:
Assesment methods:
The conditions for passing the course are in accordance with the Study Rules of the STU in Bratislava.
Learning outcomes of the course unit:
Subject the Genomics, Proteomics and their Applications deals with a rapidly evolving scientific area that introduces students into genomes, proteomes and databases that store various data about genes, proteins, genomes and proteomes. Students would learn about genomics, proteomics and bioinformatics and offer basic knowledge of genome sequencing, major differences between prokaryotic and eukaryotic genomes, basic proteomics and its applications. Students woul gain knowledge of comparative, evolutionary, human genomics and functional genomics. The acquired knowledge during the course would be helpful to those students who continue postgraduate studies.
Course contents:
1. Classification of genomics. Sequencing of genomes and sequencing methods („next-generation sequencing“). General/main databases of genomes.
2. Structure, organization and composition of prokaryotic genomes. Microbial genomics and genome epidemiology.
3. Function genomics, metagenomics and methods of metagenomics.
4. Evolution and structure of mitochondrial genomes, mtDNA and mitochondrial diseases.
5. Structure, organization and composition of eukaryotic genomes. Repetitive a transponable genetic elements and their effect on genome. Telomeric and subtelomeric regions.
6. DNA methylations, RNAi and silencing of genes expresion.
7. History of human genome sequencing. Evolution of human genome and structure variations (STR, VNTR, SNP).
8. Genomics of human diseases, nutritional genomics, epigenomics and methods of epigenomics.
9. Malditof and ESI, their use in proteomics, spectra and their analysis.
10. Tandem mass spectrometry, peptide sequencing by means of tandem mass spectrometry.
11. Affinity purification of proteins and TAP tag.
Recommended or required reading:
CVRČKOVÁ, F. Úvod do praktické bioinformatiky. Česko: Academia, 2006. 148 p. ISBN 80-200-1360-1.
BREJOVÁ, B. -- NEBOHÁČOVÁ, M. -- NOSEK, J. Genomika. Univerzita Komenského: CreateSpace Independent Publishing Platform, 2013. 276 p. ISBN 1-49373-133-5.
HEYER, L. -- CAMPBELL, A. Discovering Genomics, Proteomics and Bioinformatics. USA: Cold Spring Harbor Lab. Press, 2006. 352 p. ISBN 0-8053-4722-4.
HAWLEY, S. -- MORI, C. The human genome. Kanada: Academic Press, 2011. 420 p. ISBN 0-12333-445-4.

Language of instruction:
-- item not defined --
Courses evaluation:
Assessed students in total: 6

100,0 %0 %
Name of lecturer(s):
Ing. Svetlana Kryštofová, PhD. (examiner, instructor, lecturer) - slovak
doc. Ing. Boris Lakatoš, PhD. (person responsible for course) - slovak
Last modification:
26. 4. 2019
doc. Ing. Boris Lakatoš, PhD. and programme supervisor

Last modification made by Ing. Tomáš Molnár on 04/26/2019.

Type of output: