Oct 24, 2020   11:54 a.m. Kvetoslava
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Course syllabus 431X0_4B - Xenobiochemistry (FCFT - WS 2020/2021)

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Slovak University of Technology in Bratislava
Course unit code:
Course unit title:
Mode of delivery, planned learning activities and teaching methods:
2 hours weekly (on-site method)

Credits allocated:
Recommended semester/trimester: -- item not defined --
Level of study:
Prerequisites for registration:
Assesment methods:
running and final test
Learning outcomes of the course unit:
By studying the curriculum, students will acquire knowledge on the penetration of the xenobiotic compounds into environment, as well as on their transport in the natural milieu, and biochemical transformations thereof. The subject is based on the chemical and biochemical data, while in contrast to biochemistry, it is aimed at the transformations of the non-biological substances with the stress being put on the compounds exerting harmful activity towards health and the environment (e.g. chlorinated and polycyclic aromatics), toxicity, bioaccumulation, and persistence. Understanding of the relationships between the structure of the organic compounds and their biodegradability, and possibility of production of the toxic products during the metabolic transformation, mechanisms of action of xenobiotics-endocrinne disruptors damaging DNA in organisms is being emphasized.
Course contents:
Anthropogenic compounds, principle of their persistence and biodegradation. Persistence, toxicity and bioaccumulation of the organic pollutants. Physical and chemical properties as the factor determining behavior of the compounds in biological systems. Distribution and fate of xenobiotics in the organism. Interactions of xenobiotic molecules with a cell. Quantitative structure-activity relationships and quantitative structure-biodegradability relationships in xenobiotics. Biological degradability of organic compounds and potential toxicity of some by-products or end-products of their transformation. Toxicological aspects of the xenobiotics metabolism. Role of microbial enzymes in degradation of xenobiotics in the environment. Metabolism and cometabolism. Aerobic and anaerobic degradation of xenobiotics. Use of genetically modified microorganisms and transgenic plants at biodegradation of xenobiotics -- contaminants of the environment. Metabolic degradation pathways of aliphatic, halogenated aromatic, condensed, and polycondensed aromatic compounds.
Recommended or required reading:
HELIA, O. -- PAULIKOVÁ, I. Xenobiochémia. Bratislava : Farmaceutická fakulta UK v Bratislave, 2004. 67 p. ISBN 80-223-1796-9.
FERENČÍK, M. -- ŠKÁRKA, B. -- NOVÁK, M. -- TURECKÝ, L. Biochémia. Bratislava : SAP-Slovak Academic Press, 2000. 924 p. ISBN 80-88908-58-2.

Language of instruction:
slovak or english
Courses evaluation:
Assessed students in total: 427

48,0 %
29,7 %
16,2 %5,2 %
0,9 %
0 %
Name of lecturer(s):
doc. Ing. Katarína Dercová, PhD. (person responsible for course) - slovak, english
Last modification:
20. 4. 2020
Supervisor: doc. Ing. Katarína Dercová, PhD. and programme supervisor

Last modification made by Samuel Hraško on 04/20/2020.

Type of output: