Aug 22, 2019   7:42 a.m. Tichomír
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Ing. Peter Šafař, CSc.
Identification number: 3367
University e-mail: peter.safar [at] stuba.sk
 
Odborný asistent CSc.,PhD. - Department of Organic Chemistry (IOCP FCFT)

Contacts     Lesson     Final thesis     Projects     
Publications     Supervised theses     Conferences     

Basic information

Basic information about a final thesis

Type of thesis: Bachelor thesis
Thesis title:Stereoselective Synthesis of Indolizidinediols
Written by (author): Ing. Matej Šomodík
Department: Department of Organic Chemistry (IOCP FCFT)
Thesis supervisor: Ing. Peter Šafař, CSc.
Final thesis progress:Final thesis was successfully defended.


Additional information

Additional information about the final thesis follows. Click on the language link to display the information in the desired language.

Language of final thesis:Slovak

Slovak        English

Title of the thesis:Stereoselektívne syntézy indolizidíndiolov
Summary:Cieľom mojej bakalárskej práce bolo vhodnou metódou pripraviť (6S,7S,8S,8aS)-6-etyloktahydroindolizín-7,8-diol s trans-konfiguráciou na uhlíku C-8, ktorý môže predstavovať potenciálny inhibítor bunkových glykozidáz. Kľúčovým krokom prípravy cieľovej zlúčeniny bola trojstupňová stereoselektívna redukcia: a, C=O väzby cyklohexánového skeletu na hydroxy skupinu; b, furánového jadra na tetrahydrofuránové jadro;a c, finálna redukcia amidickej karbonylovej skupiny. Dôležitým krokom tejto syntézy bolo aj regio- a stereoselektívne otvorenie THF-kruhu. Finálny produkt (6S,7S,8S,8aS)-6-etyloktahydroindolizidín-7,8-diol bol izolovaný kolónovou chromatografiou a charakterizovaný pomocou 1H, 13C NMR spektroskopiou ako aj pomocou HMBC a HSQC metodík.
Key words:pumiliotoxíny, otváranie THF-kruhu, debromácia, indolizidíndiol

Current level of public release
 
access to digital copies of seminar papers and theses on-line via Internet after the lapse of 2 years from concluding this contract only to university users (access check based on computer's IP address or on login and password), incl. the right to provide sub-licence to a third person for study, scientific, educational and information purposes.


Display and download files

To display the final thesis assignment form click on the Display the final thesis assignment form icon. The following icons - Final thesis, Thesis appendices, Supervisor's review, Opponent's review - relate to the final thesis and can be downloaded. They could be displayed on condition they have been inserted and are available publicly.

Display the assignment form

Parts of thesis with postponed release:

Final thesis (final thesis appendices) unlimited
Reviews for final thesis unlimited