Nov 14, 2019   7:51 p.m. Irma
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Persons at STU

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Ing. Pavol Jakubec, PhD.
Identification number: 4023
University e-mail: pavol.jakubec [at]
Odborný asistent CSc.,PhD. - Department of Organic Chemistry (IOCP FCFT)
External colleague - Faculty of Chemical and Food Technology (STU)

Contacts     Lesson     Projects     Publications     Supervised theses     

Basic information

Basic information about a final thesis

Type of thesis: Bachelor thesis
Thesis title:Total Synthesis of Berkeleylactone A – Antibiotic Active Against Methicillin Resistant Staphylococcus Aureus
Written by (author): Bc. Sebastián Veselý
Department: Department of Organic Chemistry (IOCP FCFT)
Thesis supervisor: Ing. Pavol Jakubec, PhD.
Opponent:Ing. Tomáš Čarný
Final thesis progress:Final thesis was successfully defended.

Additional information

Additional information about the final thesis follows. Click on the language link to display the information in the desired language.

Language of final thesis:English

Slovak        English

Title of the thesis:Total Synthesis of Berkeleylactone A – Antibiotic Active Against Methicillin Resistant Staphylococcus Aureus
Summary:Bachelor thesis analyzes the total synthesis of enantiomerically pure berkeleylactone A - substance that has antibiotic properties against methicillin resistant strains of bacteria Staphylococcus aureus (MRSA). In the theoretical section, we discuss the situation of medicine's fight against bacteria, which progressively evolve and build tolerance to currently used antibiotics. We also look at different synthetic approaches and strategies relevant to the total synthesis of berkeleylactone A and other macrolide antibiotics. In the experimental section, we discuss in detail the chosen synthesis plan and provide data about the identification of prepared precursors.
Key words:antibiotic, berkeleylactone A, MRSA, total synthesis

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Parts of thesis with postponed release:

Final thesis (final thesis appendices) unlimited
Reviews for final thesis unlimited