Dec 14, 2019   6:51 p.m. Branislava, Bronislava
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prof. Ing. Marián Valko, DrSc.
Identification number: 4435
University e-mail: marian.valko [at] stuba.sk
 
Profesor DrSc. - Department of Physical Chemistry (IPC FCFT)
Department chief official - Department of Physical Chemistry (IPC FCFT)

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Basic information

Basic information about a final thesis

Type of thesis: Dissertation thesis
Thesis title:Interaction of redox-active metals with biomolecules
Written by (author): Ing. Patrik Poprac, PhD.
Department: Department of Physical Chemistry (IPC FCFT)
Thesis supervisor: prof. Ing. Marián Valko, DrSc.
Opponent 1:Ing. Ján Pavlik, PhD.
Opponent 2:prof. RNDr. Mariana Pajtášová, PhD.
Final thesis progress:Final thesis was successfully defended.


Additional information

Additional information about the final thesis follows. Click on the language link to display the information in the desired language.

Language of final thesis:English

Slovak        English

Title of the thesis:Interaction of redox-active metals with biomolecules
Summary:The submitted PhD Thesis is a complex study focused on the interaction of transition metal ions and newly synthesized or natural substances with the aim to demonstrate their potential clinical use in the treatment of cancer and neurodegenerative diseases. Recent research suggests that the common denominator of these civilization diseases is oxidative stress, which is the result of the action of endogenous and exogenous factors. Oxidative stress suppression is therefore an important step in the battle against the oxidative stress-related diseases. The physicochemical properties of multifunctional and natural substances under conditions simulating the in vivo environment were studied using spectral, theoretical and biochemical methods. EPR spectroscopy, UV-vis spectroscopy, gel electrophoresis, viscosimetry and other techniques were applied to study the proposed topics. Redox-metal chelating properties, controlled free radical formation, and oxidative stress suppression indicate that the studied substances could play a protective role in diseases with disrupted metal homeostasis, such as Alzheimer’s disease. The obtained results suggest that the design and investigation of multifunctional derivatives may be of key importance in the potential treatment of diseases that are multifactorial in nature and whose common denominator is oxidative stress.
Key words:Alzheimer's disease, transition metals, oxidative stress, EPR spectroscopy

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