Oct 19, 2019   9:25 p.m. Kristián
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Bc. Ľuboš Dráb
Identification number: 86685
University e-mail: xdrabl [at] stuba.sk
1420T11  Technical Chemistry I-TCHEM
FCFT I-TCHEM-OCH den [term 1, year 1]
Master type of study, full-time, attendance method form
organická chémia, 1st year of study / 1st semester of study
Study group no.: 53

Contacts     Graduate     Final thesis     Publications     

Basic information

Basic information about a final thesis

Type of thesis: Bachelor thesis
Thesis title:DMSO methylations of heteroaromates
Written by (author): Bc. Ľuboš Dráb
Department: Department of Organic Chemistry (IOCP FCFT)
Thesis supervisor: doc. Ing. Peter Szolcsányi, PhD.
Opponent:Ing. Ondrej Záborský, PhD.
Final thesis progress:Final thesis was successfully defended.

Additional information

Additional information about the final thesis follows. Click on the language link to display the information in the desired language.

Language of final thesis:Slovak

Slovak        English

Title of the thesis:DMSO methylations of heteroaromates
Summary:The Bachelor Thesis contains a literature review of current knowledge of radical methylation of (hetero)aromatics using a methyl radical generated by Fenton's reagent from DMSO for the formation of a new C-C bond following the AdR mechanism, as well as other methods of generating a methyl radical. The literature review also includes alternative mechanisms leading to new C-C bond using DMSO. With the aim to investigate the possible synthetic utility of such radical methylation, we have applied a precedented reaction conditions using DMSO, Fenton's reagent and sulfuric/ trifluoroacetic acid, in the reaction screening of various 5-/6-membered substituted N-heteroaromatics based on imidazole, pyridine, pyrazine and purine. From a total 11 substrates, only in 5 cases we analytically detected the formation of expected methylated products. In most cases, we observed either zero conversion of substrates and/or formation of complex reaction mixtures free of desired merthylated products.
Key words:radical methylation, C-C bond formation, DMSO, Fenton's reagent, N-heteroaromatics, reactivity

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