Oct 16, 2019   9:13 a.m. Vladimíra
Academic information system

Summary of topics offered - Institute of Biochemistry and Microbiology (FCFT)


Basic information

Type of work: Bachelor thesis
Topic: Fylogenetická analýza fungálneho GABA skratu
Title of topic in English: Phylogenetic analysis of fungal GABA shunt
State of topic: approved (doc. Ing. Daniela Šmogrovičová, PhD. - Study programme supervisor)
Thesis supervisor: Ing. Svetlana Kryštofová, PhD.
Faculty: Faculty of Chemical and Food Technology
Supervising department: Institute of Biochemistry and Microbiology - FCFT
Max. no. of students: 1
Academic year:2018/2019
Proposed by: Ing. Svetlana Kryštofová, PhD.
Summary: GABA skrat v eukaryotických bunkách obchádza reakcie TCA cyklu katalyzované 2-ketoglutarátdehydrogenázou a sukcinyl CoA syntetázou. GABA je syntetizovaná z glutamátu glutamátdekarboxylázou (GAD) v cytoplazme. Odtiaľ je potom transportovaná do matrixu mitochondrií, kde je konvertovaná GABA transaminázou (GABAT) a sukcinylsemialdehyddehydrogenázou (SSADH) na sukcinát. Cieľom tejto práce je vyhľadanie proteínových sekvencií pre enzýmy GABA skratu v hubách a ich fylogenetická analýza využitím bioinformatických nástrojov.



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Restrictions by study
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Programme
B-BIOT Biotechnology

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