Sep 21, 2019   3:04 p.m. Matúš
Academic information system

Summary of topics offered - Institute of Biochemistry and Microbiology (FCFT)


Basic information

Type of work: Dissertation thesis
Topic: Zmeny v expresnom profile proteínov pri rozvoji viacliekovej rezistencie v leukemických bunkach
Title of topic in English: Alterations in proteeins´expression profile during multidrug resistance development in leukemia cells.
State of topic: approved (prof. Ing. Albert Breier, DrSc. - Chairperson of Departmental Board)
Thesis supervisor: prof. Ing. Albert Breier, DrSc.
Faculty: Faculty of Chemical and Food Technology
Supervising department: Institute of Biochemistry and Microbiology - FCFT
Max. no. of students: --
Academic year:2019/2020
Proposed by: prof. Ing. Albert Breier, DrSc.
External educational institution: Centre of Biosciences of the Slovak Academy of Sciences
Annotation: Rozvoj viacliekovej rezistencie (MDR) je často príčinou zníženej citlivosti leukemických buniek na chemoterapeutiká. Najatejšie je MDR spôsobená nadexpresiou P-glykoproteínu, ktorý je efluxnou pumpou plazmatickej membrány z širokou substrátovou špecificitou. V priebehu rozvoja MDR však dochádza k výrazným zmenám v expresnom profile rôznych proteínov, čo odpovedá zmenenému fenotypu leukemických buniek. Toto sa bude študovať v predloženej téme
Annotation in English: Development of multidrug resistance represents often causality of cell sensitivity to antileukemic drugs in leukemia cells. Expression of P-glycoprotein, a drug efflux pump of plasma membrane with large substrate specificity, is most often observed molecular feature in MDR induction. However during MDR development massive changes of proteins´ expression profile take parts, which reflecting altered phenotype of leukemia cells. This issue will be study in the current theme.



Limitations of the topic

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Limit to study programme
The table shows limitations of study programme, field, track the student has to be enrolled in to be able to register for a given topic.

ProgrammeTrackTrack
D-BICH Biochemistry-- not entered -- -- not entered --