Oct 14, 2019   12:25 p.m. Boris
Academic information system

Summary of topics offered - Slovak university of technology in Bratislava

Basic information

Type of work: Dissertation thesis
Topic: Zmeny v expresnom profile proteínov pri rozvoji viacliekovej rezistencie v leukemických bunkach
Title of topic in English: Alteration in leukemia cells biological memebranes structure/function associated with P-gp mediated multidrug resistance developmet.
State of topic: approved (prof. Ing. Albert Breier, DrSc. - Chairperson of Departmental Board)
Thesis supervisor: prof. Ing. Albert Breier, DrSc.
Faculty: Faculty of Chemical and Food Technology
Supervising department: Institute of Biochemistry and Microbiology - FCFT
Max. no. of students: --
Academic year:2019/2020
Proposed by: prof. Ing. Albert Breier, DrSc.
Annotation: Pri rozvoji viacliekovej rezistencie v leukemických bunkách často dochádza k výraznej nadexpresii membránovej efluxnej pumpy - P-glykoproteínu. Zmenený fenotyp rezistentných leukemických buniek zahŕňa zmeny v expresnom profile viacerých proteínov. Ukazuje sa, že dochádza aj k zmenám v zložení biologických membrán, čo môže spôsobovať zmenu v ich permeabilných charakteristikách. Výskum v tejto oblasti je zadaním predloženej témy.
Annotation in English: Development of multidrug resistance represents often causality of cell sensitivity to antileukemic drugs in leukemia cells. Expression of P-glycoprotein, a drug efflux pump of plasma membrane with large substrate specificity, is most often observed molecular feature in MDR induction. However during MDR development massive changes of proteins´ expression profile take parts, which reflecting altered phenotype of leukemia cells. This issue will be study in the current theme.

Limitations of the topic

To sign up for a topic it is necessary to fulfil one of the following restrictions

Omezení dle studia
The table shows limitations of study programme, field, track the student has to be enrolled in to be able to register for a given topic.

D-BICH Biochemistry