Oct 14, 2019   3:35 p.m. Boris
Academic information system

Summary of topics offered - Institute of Chemical and Environmental Engineering (FCFT)


Basic information

Type of work: Dissertation thesis
Topic: Chromatografická separácia fenyletanoidných glykozidov
Title of topic in English: Chromatographic separation of phenyletanoid glycosides
State of topic: approved (prof. Ing. Jozef Markoš, DrSc. - Chairperson of Departmental Board)
Thesis supervisor: prof. Ing. Milan Polakovič, CSc.
Faculty: Faculty of Chemical and Food Technology
Supervising department: Department of Chemical and Biochemical Engineering - ICEE FCFT
Max. no. of students: --
Academic year:2019/2020
Proposed by: prof. Ing. Milan Polakovič, CSc.
Annotation: Hlavným zámerom dizertačnej práce je vyšetrovanie procesov produkcie málo preskúmaných fenyletanoidných zlúčenín, β-fruktofuranozidov a β-galaktopyranozidov tyrozolu a hydroxytyrozolu, ktoré môžu poskytnúť rad nových potenciálnych liečiv. Táto téma nadväzuje na nedávno začatý výskum, ktorý sa zameriava na biokatalytickú produkciu fenyletanoidných glykozidov. V dôsledkej neúplnej premeny substrátov a vedľajších reakcií želaný produkt sa musí izolovať z pestrej zmesi sacharidov, glykozidov a fenolických látok vo viacerých chromatografických krokoch. Vývoj týchto procesov bude predmetom dizertačnej práce.
Annotation in English: The main objective of the PhD. study is the investigation of processes of less-known phenylethanoid compounds, β-fructofuranosides and β-galactopyranosides of tyrosol and hydroxytyrosol, that may provide a scale of new potential drugs. This topic continues the recently started research on the biocatalytic production of phenyletanoid glycosides. Due to uncomplete conversion of substrates and side reactions, the required product must be isolated from a complex mixture of saccharides, glycosides and phenolic compounds in several chromatographic steps. The development of these processes will be the subject of PhD. thesis.



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Omezení dle studia
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Programme
D-CHEI Chemical Engineering
D-CHEIxA Chemical Engineering