Oct 16, 2019   0:07 a.m. Vladimíra
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Summary of topics offered - Faculty of Chemical and Food Technology


Basic information

Type of work: Dissertation thesis
Topic: Imobilizované rekombinantné celobunkové biokatalyzátory pre produkciu chemických špecialít pomocou kaskádových reakcií
Title of topic in English: Immobilized recombinant whole-cell biocatalysts for production of chemical specialties using cascade reactions
State of topic: approved (Dr.h.c. prof. Ing. Ján Šajbidor, DrSc. - Chairperson of Departmental Board)
Thesis supervisor: Ing. Marek Bučko, PhD.
Faculty: Faculty of Chemical and Food Technology
Supervising department: Institute of Biotechnology - FCFT
Max. no. of students: --
Academic year:2019/2020
Proposed by: Ing. Marek Bučko, PhD.
External educational institution: Institute of Chemistry of the Slovak Academy of Sciences
Annotation: Cieľom dizertačnej práce je vývoj imobilizovaných celobunkových biokatalyzátorov na báze viabilných rekombinantných mikroorganizmov pre zvýšenie produktivity prekurzorov na syntézu bioaktívnych látok a potenciálnych liečiv. Bude využitá kaskáda redoxných enzýmov koexprimovaných v baktériách a tiež rekombinantné bunky s naprodukovanými enzýmami Baeyer-Villigerovými monooxygenázami. Bunky budú stabilizované imobilizáciou v polyelektrolytových časticiach a kapsuliach a charakterizované s využitím unikátnych techník v spolupráci so špičkovými domácimi a zahraničnými pracoviskami.
Annotation in English: The aim of the dissertation is to develop immobilized whole cell biocatalysts based on viable recombinant microorganisms for increasing the productivity of precursors for the synthesis of bioactive substances and potential drugs. The cascade of redox enzymes co-expressed in bacteria as well as recombinant cells with overproduced enzymes Baeyer-Villiger monooxygenases will be used. Cells will be stabilized by immobilization in polyelectrolyte complex particles and capsules and characterized using unique techniques in collaboration with leading domestic and foreign institutes.



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Programme
D-BIOT Biotechnology