Cytotoxicity of novel xenobiotics and their mode of action.Supervisor: doc. Ing. Soňa Jantová, CSc.
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|Project description:||Therefore the cytotoxic, genotoxic and antimicrobial properties of the chemical compounds of the different structure will be evaluated. Special attention will be focused to the mechanism of the action and the cytotoxic activity of chosen most active derivatives of oracine, organic ammonium salts, Cu++complexes, ITC and quinazoline; notably the interference on the biosynthesis of macromolecules, the interference with the cell cycle, their ability to induce apoptosis in different tumour cell lines as well as the influence actin cytosceleton and the intracellular pH. The series of phenolic compounds and polyphenolic lignin derivatives will be investigated from the view point of their antimutagenic, antioxidative and adsorptive effect. The mechanism of these effects will be studied. Modulation of glutathione metabolism can provide a strategy for more efficacious sensitization of tumor cells to a standard anticancer drugs (doxorubicin) in chemotherapy and anticancer activity of new modulators of glutathione relative enzyme will be investigated.|
|Kind of project:||VEGA ()|
|Department:||Department of Biochemistry and Microbiology (IBM FCFT)|
|Project status:||Successfully completed|
|Project start date :||01. 01. 2004|
|Project close date:||31. 12. 2006|
|Number of workers in the project:||1|
|Number of official workers in the project:||0|