Synthesis and properties of new potentially biologically active heterocyclic compounds utilizable in supramolecular chemistry and nanotechnologies.Supervisor: prof. Ing. Viktor Milata, DrSc.
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|Project description:||Study and optimalisation of the new synthetic methods for preparation of analogues of natural condensed aromatic polyazaheterocyclic compounds with fused aromatic or saturated ring containing O, S, Se or N atoms. Preparation of precursors of cited heterocycles and their nitro- and aminoderivatives, imidoylchlorides, imidoyl and amidinoylisothiocyanates. Exploitation of new precursors in cyclisation and cyclocondesation reactions for preparation of target compounds. Derivatisation of newly prepared heterocyclic compounds by introduction of carbohydrate or other hydrophylic part aiming to higher solubility of prepared compounds allowing their more effective biological application. Study of physico-chemical properties and spectral characteristics of final derivatives in relation to their X-ray structural analysis, supramolecular chemistry using quantum-chemical calculations.|
|Kind of project:||APVV ()|
|Department:||Department of Organic Chemistry (IOCP FCFT)|
|Project status:||Successfully completed|
|Project start date :||01. 01. 2005|
|Project close date:||31. 12. 2007|
|Number of workers in the project:||1|
|Number of official workers in the project:||0|