Study of stereoselective transformations of non-proteinogenic gamma-oxo-alpha-aminocarboxylic acidsSupervisor: doc. Ing. Dušan Berkeš, CSc.
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|Project description:||Synthesis of enantiomerically pure, conformationally restricted derivatives of homophenylalanine and its heteroanalogs by crystallization-induced asymmetric transformation (CIAT) coupled with the aza-Michael addition and electrophilic lactonization. Study of simultaneous CIAT taking place at two stereogenic centers. Utilization of such asymmetric transformation in the synthesis of natural polysubstituted amino acids and their derivatives. Stereoselective transformations of the prepared gamma-oxosubstituted alpha-aminocarboxylic acids. Preparation of 5-aryl-substituted 3-amino-2-hydroxytetrahydrofurans and study of their conversion to optically pure substituted C-aryl amino-furanosides.|
|Kind of project:||VEGA ()|
|Department:||Department of Organic Chemistry (IOCP FCFT)|
|Project status:||Successfully completed|
|Project start date :||01. 01. 2005|
|Project close date:||31. 12. 2007|
|Number of workers in the project:||1|
|Number of official workers in the project:||0|