Sep 21, 2019   3:04 p.m. Matúš
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The role of proton-motive force in the Ca2+ homeostasis in filamentous fungi.

Supervisor: doc. Ing. Martin Šimkovič, PhD.


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Project description:Ca2+ homeostasis represents an integrating system of every living cell and plays a crucial role in the regulation of numerous functions on both cellular and organismic levels. There are only scarce knowledge on the Ca2+ homeostasis in filamentous fungi which are scattered among several fungal species. Recently, we described properties of partial reactions of Ca2+ homeostasis and their developmental changes in deuteromycete Trichoderma viride. We found that uncouplers stimulated both Ca2+ influx and efflux across the cytoplasmic membrane. This means that the electrochemical potential of H+ couples the Ca2+ translocation across this membrane. This observation is important for the understanding of Ca2+ homeostasis and opens new views on the physiology of fungi and its intentional manipulation. This project is mainly devoted to the analysis of this phenomenon, to ascertaining its universality and/or specificity. A part of this project will be devoted to experiments which could elucidate the role of Ca2+ in the signalling pathway triggering the light-induced conidiation in Trichoderma viride.
Kind of project:VEGA ()
Department:Department of Biochemistry and Microbiology (IBM FCFT)
Project identification:1/2335/05
Project status:Successfully completed
Project start date :01. 01. 2005
Project close date:12. 12. 2007
Number of workers in the project:1
Number of official workers in the project:0