Chemical toxicity sensors ? investigation of selected environmental risk factors using biosensors based on DNA and LDL.Supervisor: prof. Ing. Ján Labuda, DrSc.
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|Project description:||Detection of chemical association interactions and damage to deoxyribonucleic acid (DNA) and lipoproteins (LDL) can serve for rapid and inexpensive screening of the chemicals toxicity. Biosensors using these biocomponents for the molecular recognition of analyte belong to modern analytical devices with a fast development. Within the project, chemical interactions of environmental carcinogens such as arsenic and tin compounds as well as selected aromatic and heterocyclic compounds, in particular their nitro-derivatives, with DNA and LDL immobilized on the surface of electrochemical signal transducers will be investigated. Application of the electrochemical biosensors allows also in vitro generation and testing of potential metabolites and an investigation of mechanisms of risk species effects. This leads to the methodical development of new screening tools based on biosensors and bioelectronic chips. Possibilities of the biopolymers protection against a structural damage by environmental carcinogens using natural and synthetic antioxidants will be studied too.|
|Kind of project:||VEGA ()|
|Department:||Department of Analytical Chemistry (IAC FCFT)|
|Project status:||Successfully completed|
|Project start date :||01. 01. 2005|
|Project close date:||31. 12. 2007|
|Number of workers in the project:||1|
|Number of official workers in the project:||0|