Novel complexes of bioligands: synthesis, structure, properties and applications.Supervisor: prof. RNDr. Milan Melník, DrSc.
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|Project description:||Investigation of new metal complexes exhibiting controlled antiphlogistic and antituberculotic effects is an important task of contemporary bioinorganic chemistry. The project is focused on a complete research of the formation, structure, properties and practical applications of copper, iron, zinc and other metal complexes with non-steroid antiphlogistics (derivatives of salicylic and propionic acids, fenamates) and antituberculotics (derivatives of quinolons, nicotinic acid, nicotinamide, pyridylcarbinol and imidazole). The synthesized complexes will be studied as solids and in the solutions by x-ray diffraction of crystals and powders, spectral, magnetic, thermal, electrochemical and photochemical methods. Obtained characterization of the compounds will be compared and confronted with literature data in order to extract trends related to important biological aspects. A basic biological screening of the prepared complexes will be focused on cytotoxicity and its mechanisms.|
|Kind of project:||VEGA ()|
|Department:||Department of Inorganic Chemistry (IICTM FCFT)|
|Project status:||Successfully completed|
|Project start date :||01. 01. 2005|
|Project close date:||31. 12. 2007|
|Number of workers in the project:||1|
|Number of official workers in the project:||0|