May 24, 2019   10:49 a.m. Ela
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Antioxidant and prooxidant properties of carotenoids. (An Electron Paramagnetic Resonance study).

Supervisor: prof. Ing. Marián Valko, DrSc.

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Project description:Carotenoids are pigments that are found in plants and microorganisms and may prevent or inhibit certain types of cancer, atherosclerosis, age-related muscular degeneration, and other diseases. The protective role of carotenoids is related to their antioxidant ability to efficiently scavenge free radicals. The main objective of this project is to perform a comparative study of antioxidant efficiency of several carotenoids to scavenge oxygen free radicals in solution. However, recent epidemiological studies have surprisingly demonstrated that some carotenoids can also exhibit prooxidant properties. In this connection we plan to investigate the most important factors, such as concentration, role of trace metals (Cu2+, Fe2+), isomerism and oxygen partial pressure (pO2), which affect a switch between antioxidant and prooxidant behaviour of carotenoids using EPR spectroscopy. In particular the role of cis-trans isomerism within the conjugated chain, which recent biochemical experiments suggest might have a very significant effect on activity, has received little attention.
Kind of project:VEGA ()
Department:Department of Physical Chemistry (IPC FCFT)
Project identification:1/2450/05
Project status:Successfully completed
Project start date :01. 01. 2005
Project close date:31. 12. 2007
Number of workers in the project:1
Number of official workers in the project:0