The role of H+ homeostasis in adaptive responses of nutrient transport in filamentous fungi.Supervisor: prof. RNDr. Ľudovít Varečka, DrSc.
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|Project description:||We found earlier that the citrate and glutamate transport into Deuteromycete Trichoderma viride is only facultatively dependent on the proton-motive force (pmf) that is they become dependent upon the pmf only after their adaptation to the presence of these compounds. On the other hand, the uracil transport was constitutively dependent on the pmf. It is feasible that pmf is not a constant cellular parameter of filamentous fungi and its magnitude varies upon changes in external conditions. It is also feasible that the magnitude of pmf could be a subject of yet unknown cellular regulatory mechanisms. Furthemore, the response of filamentous fungi to the insufficient magnitude of pmf will be investigated. The goal of this project is to outline the role of pmf as driving force for the transport of selected nutrients and for the regulation of related metabolic pathways. Other goal is to understand mechanisms underlying the changes in pmf during the adaptation to non-saccharidic substrates and mechanisms used by fungi during the growth under conditions of low pmf.|
|Kind of project:||VEGA ()|
|Department:||Department of Biochemistry and Microbiology (IBM FCFT)|
|Project status:||Successfully completed|
|Project start date :||01. 01. 2006|
|Project close date:||31. 12. 2008|
|Number of workers in the project:||1|
|Number of official workers in the project:||0|