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Syntheses directed towards novel pi-conjugated heterocyclic compounds such that show opto-electronic properties, specific bioactivity, and apoptosis.

Supervisor: Ing. Daniel Végh, DrSc.


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Project description:Design of syntheses, supported by theoretical studies, of novel heterocyclic compounds. Synthesis of derivatives of novel pi-conjugated heterocycles of the thiophene, pyrrole, furan imidazole, pyriazine, fluorene and anthrone derivatives series as well as of their bioactivity. Study of controlled dimerization and trimerization of the synthesized pi-conjugated heterocyclic compounds for preparation of molecular and supramolecular functional units and nanostructures. Synthesis of thiophene oligomers in the channels of a synthetic zeolite and at the surface of inorganic semiconductor (TiO2). Modeling of novel supramolecular units and potential pi-conjugated antenna systems pro molecular recognition and self-assembly by utilizing theoretical calculations and combination of various building blocks.Synthesis and utilization of perfluoroaromatics for molecular recognition. Synthesis and modelling of structure of compounds active against cancer and launching apoptosis.
Kind of project:VEGA ()
Department:Department of Organic Chemistry (IOCP FCFT)
Project identification:1/4453/07
Project status:Successfully completed
Project start date :01. 01. 2007
Project close date:31. 12. 2009
Number of workers in the project:1
Number of official workers in the project:0