Genetically engineered microorganisms as whole-cell catalysts of enantioselective biooxidations performing by novel immobilization biotechnologies.Supervisor: doc. Ing. Vladimír Štefuca, CSc.
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|Project description:||The project is aimed in development of a new biotechnological process for Baeyer-Villiger biooxidations. The process will use a new generation of recombinant bacterial cells E. coli with Baeyer-Villiger monooxigenases (BVMO) catalyzing enantioselective Baeyer-Villiger oxidation of chosen bicyclic ketones to corresponding lactones needed as chiral syntones for chemical/enzymatic synthesis of pharmaceuticals with similar structures (D-(+)-showdomycine, ribavirin and their analogues) active against infectious deseases. The biotechnological BVMO process will include implementation od immobilized whole cell biocatalysts E. coli.|
|Kind of project:||APVV ()|
|Department:||Department of Chemical and Biochemical Engineering (ICEE FCFT)|
|Project status:||Successfully completed|
|Project start date :||01. 05. 2006|
|Project close date:||30. 04. 2009|
|Number of workers in the project:||2|
|Number of official workers in the project:||0|