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Genetically engineered microorganisms as whole-cell catalysts of enantioselective biooxidations performing by novel immobilization biotechnologies.

Supervisor: doc. Ing. Vladimír Štefuca, CSc.

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Project description:The project is aimed in development of a new biotechnological process for Baeyer-Villiger biooxidations. The process will use a new generation of recombinant bacterial cells E. coli with Baeyer-Villiger monooxigenases (BVMO) catalyzing enantioselective Baeyer-Villiger oxidation of chosen bicyclic ketones to corresponding lactones needed as chiral syntones for chemical/enzymatic synthesis of pharmaceuticals with similar structures (D-(+)-showdomycine, ribavirin and their analogues) active against infectious deseases. The biotechnological BVMO process will include implementation od immobilized whole cell biocatalysts E. coli.
Kind of project:APVV ()
Department:Department of Chemical and Biochemical Engineering (ICEE FCFT)
Project identification:APVV-51-033205
Project status:Successfully completed
Project start date :01. 05. 2006
Project close date:30. 04. 2009
Number of workers in the project:2
Number of official workers in the project:0