Oct 18, 2019   7:02 a.m. Lukáš
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Synthetic studies of substituted oxoamino acids and their derivatives.

Supervisor: doc. Ing. Dušan Berkeš, CSc.

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Project description:Synthesis of diastereomerically and enantiomerically enriched oxoaminosubstituted (gama-oxo-alfa-amino; delta-oxo-gama-amino resp. N-(beta-oxoalkyl)) carboxylic acids using a tandem of oxo-enol tautomerism and crystallization-induced asymmetric transformation (CIAT). Direct three-component Mannich reaction of free glyoxylic acid in tandem with CIAT process ? synthesis of optically active sunatituted aroylalanines. Synthetic study of their stereoslective transformations targeting to the homologues of statine analogues AHPPA and ACHPA. Intramolecular Michael addition of the enolates of N-substituted gama-oxo-alfa-aminocarboxylic acids - diastereoselective synthesis of polysubtituted pyroglutamic acids and spiropyrrolidinyl-oxindoles.
Kind of project:VEGA ()
Department:Department of Organic Chemistry (IOCP FCFT)
Project identification:1/0629/08
Project status:Successfully completed
Project start date :01. 01. 2008
Project close date:31. 12. 2010
Number of workers in the project:2
Number of official workers in the project:0