Sep 19, 2019   4:40 p.m. Konštantín, pamätný deň - Deň prvého verejného vystúpenia Slovenskej národnej rady
Academic information system

Projects


Synthetic studies of substituted oxoamino acids and their derivatives.

Supervisor: doc. Ing. Dušan Berkeš, CSc.


Basic information   Workers      


This page shows details on the project. The primary projects are displayed together with a list of sub-projects.

Project description:Synthesis of diastereomerically and enantiomerically enriched oxoaminosubstituted (gama-oxo-alfa-amino; delta-oxo-gama-amino resp. N-(beta-oxoalkyl)) carboxylic acids using a tandem of oxo-enol tautomerism and crystallization-induced asymmetric transformation (CIAT). Direct three-component Mannich reaction of free glyoxylic acid in tandem with CIAT process ? synthesis of optically active sunatituted aroylalanines. Synthetic study of their stereoslective transformations targeting to the homologues of statine analogues AHPPA and ACHPA. Intramolecular Michael addition of the enolates of N-substituted gama-oxo-alfa-aminocarboxylic acids - diastereoselective synthesis of polysubtituted pyroglutamic acids and spiropyrrolidinyl-oxindoles.
Kind of project:VEGA ()
Department:Department of Organic Chemistry (IOCP FCFT)
Project identification:1/0629/08
Project status:Successfully completed
Project start date :01. 01. 2008
Project close date:31. 12. 2010
Number of workers in the project:2
Number of official workers in the project:0