Synthetic studies of substituted oxoamino acids and their derivatives.Supervisor: doc. Ing. Dušan Berkeš, CSc.
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|Project description:||Synthesis of diastereomerically and enantiomerically enriched oxoaminosubstituted (gama-oxo-alfa-amino; delta-oxo-gama-amino resp. N-(beta-oxoalkyl)) carboxylic acids using a tandem of oxo-enol tautomerism and crystallization-induced asymmetric transformation (CIAT). Direct three-component Mannich reaction of free glyoxylic acid in tandem with CIAT process ? synthesis of optically active sunatituted aroylalanines. Synthetic study of their stereoslective transformations targeting to the homologues of statine analogues AHPPA and ACHPA. Intramolecular Michael addition of the enolates of N-substituted gama-oxo-alfa-aminocarboxylic acids - diastereoselective synthesis of polysubtituted pyroglutamic acids and spiropyrrolidinyl-oxindoles.|
|Kind of project:||VEGA ()|
|Department:||Department of Organic Chemistry (IOCP FCFT)|
|Project status:||Successfully completed|
|Project start date :||01. 01. 2008|
|Project close date:||31. 12. 2010|
|Number of workers in the project:||2|
|Number of official workers in the project:||0|