Stereoselective palladium catalysed cyclisations and cross-coupling reactions in natural product synthesisSupervisor: prof. Ing. Tibor Gracza, DrSc.
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|Project description:||Development of new synthetic methodology for synthesis of oxa- and azaheterocyclic compounds with defined configuration at all stereogenic centers. The application of the methodologies in the syntheses of natural products and biologically interesting compounds. Study of chemo-, diastereo- and substrate selectivity of palladium(II)-catalysed cyclisation of unsaturated polyols. Exploration of the reaction by trapping of intermediary sigma-alkyl Pd(II)-complex in the domino reaction with subsequent C-C, C-O, C-N cross-coupling reactions. The application of the domino reactions for construction of dioxa[2.2.1]bicyclic skeletons, polyhydroxylated tetrahydrofurans, tetrahydropyrans, pyrrolidines and piperidines with defined stereochemistry. Synthetic strategies will be applied in the total syntheses of natural C-15 acetogenins, goniothalesdiols, varitriol and deoxyanhydroaminoalditols. Synthesis of modified isoxazolidinyl nucleosides using Pd-catalysed cross-coupling reactions.|
|Kind of project:||VEGA ()|
|Department:||Department of Organic Chemistry (IOCP FCFT)|
|Project status:||Successfully completed|
|Project start date :||01. 01. 2010|
|Project close date:||31. 12. 2011|
|Number of workers in the project:||11|
|Number of official workers in the project:||0|