Oct 20, 2019   11:08 a.m. Vendelín
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The combination of crystallization-induced asymmetric transformation and metal catalyzed transformations as an efficient way of utilization of the synthetic potential of amino acids in the preparation of biologically active natural substances

Supervisor: doc. Ing. Andrej Kolarovič, PhD.

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Project description:The project is oriented to study the phenomenon of crystallization-induced asymmetric transformation, and its' practical utilisation in the synthesis of a series nonproteinogenic beta-, gamma- and delta-amino acids. The reported regioisomeric amino acids as such are attractive synthetic targets, and after the appropriate functionalisation will serve as effective building blocks for the development of Pd-catalyzed transformations. Here we rank oxidations/carbonylations, hydroaminations and cross-couplings of functionalised substrates, leading to sophisticated synthetic intermediates. These will serve as key molecules in the stereoselective total syntheses of biologically active natural substances and their functional analogues. Target compounds are potentially useful for both chemo-enzymatic studies, and biological screening.
Kind of project:VEGA ()
Department:Department of Organic Chemistry (IOCP FCFT)
Project identification:1/0340/10
Project status:Successfully completed
Project start date :01. 01. 2010
Project close date:31. 12. 2011
Number of workers in the project:5
Number of official workers in the project:0