Stereoselective syntheses of chiral 1,4-dihydropyridines and analogs of indolizine type alkaloids.Supervisor: prof. Ing. Štefan Marchalín, DrSc.
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|The principal goal of the project is to investigate posible utilization of 2-formyl-1,4-dihydropyridines in the synthesis of novel chiral 2-substituted dihydropyridines, polycyclic heterocycles respectively, containing a 1,4-dihydropyridine ring and dihydroindolizines. Preparation and characterization of coordination compounds of both transition and non transition metals carrying 1,4-dihydropyridine based ligands, examination of their composition, structure, and investigation of their catalytic activity. The project aims at preparation of carefully designed substituted indolizines and indolizidines ? compounds with possible bioactivity. Practical application of regio-, chemo- and stereoselective reactions making use of novel features of organic synthesis. Elaboration of novel, simple, and generally applicable stereocontrolled syntheses of pure analogs of indolizine type alkaloids, utilizing chiral synthons based on hetero[f]indolizidinediones.|
|Kind of project:||VEGA ()|
Department of Organic Chemistry (IOCP FCFT)
|Project start date :||01. 01. 2005|
|Project close date:||31. 12. 2007|
|Number of workers in the project:|
Number of official workers in the project: